Intrakavernoznye injection of vasoactive drugs

Method intrakavernoznyh injection of vasoactive drugs in a fairly common and effective methods among conservative restoration of sexual function.

For the treatment of impotence using papaverine, phentolamine and prostaglandin E1, both as monotherapy and in their various combinations.

Papaverine was the first drug used for intrakavernoznyh injection. The practical application showed a fairly high efficiency of the drug for the restoration of sexual function (60-80%). Monotherapy impotence papaverine is limited in duration due to the high risk of cavernous fibrosis, priapism and hepatotoxicity of the drug.
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Safer drugs for intrakavernoznogo application is prostaglandin E1. Effectiveness of the method intrakavernoznyh injection of prostaglandin E1 is 70-80%.
Intrauretralnaya treatment of erectile dysfunction

For intrauretralnyh applications used the drug alprostadil, the active ingredient of which is prostaglandin E1. From the urethra drug absorbed from the bloodstream and enters the cavernous body, which causes a cascade of reactions leading to increased blood filling the cavernosal tissue and create an erection.

The action of the drug, introduced intrauretralno, the same as when intrakavernoznom introduction. Intrauretralnaya therapy is an effective method of restoring erections (60-70%), allowing to exclude an injection into the penis.

Transurethral system for the introduction of vasoactive drugs is a polypropylene applicator containing a single dosage (MUSE). One side effect was noted pain in the penis, rarely leads to cessation of treatment.

After urinating tip of the applicator gently introduced into the opening of urethra to a depth of about 3 cm residual urine serves as a "lubricant" for the tip of the applicator and solvent for the drug. By pressing a special button on the end of the applicator medicine (for consistency and properties resembling suppository) is introduced into the urethra. After that, the applicator is removed from the hole urethra. Within 10 seconds, the patient should massage the penis for better dispersion of the drug.

At present, proved highly effective in transurtralnom PGE1 infusion. At the same time stated the poor efficiency of this method of treatment in patients with the organic nature of the disease.